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Unfortunately for Sinister Apocalypse's ability for his molecular structure to adapt is able to fight the virus and is only weakened by it.He threatens Sinister if they were to ever meet again, Apocalypse would kill him. This partially drove his desire to find and create a powerful mutant in order to defeat Apocalypse later on.Returning to Nur's Ship, Nur demanded to know why the plague was not complete and Mr.Sinister stated that he manipulated the plague, so that it would affect only Nur himself, but his immune system quickly adapted to it. Sinister replied that cruelty for no purpose was ignorance and ignorance was the greatest enemy of science.Feeling threatened by the power of Nur, Sinister conducted numerous experiments in his time, searching for a powerful mutant to oppose his master and the means to improve himself.For a time, Sinister continued to advance his master plan to serve Nur (and his own ends), but in general preferred to let bloodlines breed naturally (rather than hastily transforming them), in order to produce the most racially-supreme beings.In the 1920s, Sinister encountered and influenced the work of a man named Herbert Edgar Wyndham, who dreamed of doing what Sinister had already accomplished—breaking the genetic code for human DNA.During a trip to an international conference on genetics in Geneva, Switzerland, Wyndham suddenly felt ill.

Essex believed that the sanctity and purity of it was heaven on Earth. Essex later became a biologist in 1859 Victorian England. Essex was regarded, by some, to be the greatest scientific mind of his generation, and, by others, as a dangerous man twisted by the obsession of his own research. Essex believed in Darwin's theory of evolution and discovered that humanity was undergoing increasing mutation, due to what he called “Essex Factors” in the human genome. Essex also believed that, in the offspring of certain racially superior individuals, these parcels will, within a hundred years or so, mutate. Essex's theories were mocked, making him bitter, and his revealing of an unorthodox experiment resulted in his ousting from the Royal Society. Essex see a physician due to the trauma of losing his son. Essex stated to Darwin that if becoming a monster was what was required for science to progress, then he would become a monster. Essex was taken underground, where the Mauraders were collecting freaks, fools, and all types of misshapen folk off the streets of London. Essex hired the thugs to continue their work, so he could perform experiments on the victims in the name of science.

In 1882, Sinister was present at Darwin's funeral, reveling in the irony that the man who was once vilified was being buried in Westminster Abbey, the highest church of England.

As he walked away, Sinister mused why he kept a small box containing a picture of his wife if he truly left his humanity behind.

After the time-traveling duo defeated Nur and began to shift back to their own time, Mr.

Sinister appeared and stated to Cyclops that he was sure they would meet again.

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